Which ion is considered the major extracellular ion?

Sodium is recognized as the major extracellular ion due to its predominant presence and critical role in maintaining fluid balance, osmotic pressure, and overall cellular function. It is primarily found outside of cells in the extracellular fluid, including blood plasma, which makes up a substantial portion of the body's total fluid volume.

Sodium ions contribute significantly to the generation and propagation of action potentials in neurons and muscle cells, facilitating communication and contraction. The sodium-potassium pump, an essential membrane protein, actively transports sodium out of cells while bringing potassium in, thereby maintaining the electrochemical gradient necessary for physiological processes.

This role of sodium underscores its importance in numerous bodily functions, such as regulating blood pressure, volume, and pH balance. The abundance of sodium in the extracellular space relative to other ions also underscores its position as a key player in extracellular ion dynamics.